生物学描述Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.
存放说明Store at -20°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
溶解度概述Soluble in ethanol to 10 mM and in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Trichostatin A inhibits histone deacetylases in NIH/3T3 cells.
Cells from logarithmic were incubated overnight with different concentrations of Trichostatin A (ab120850). Cell proteins were resolved by SDS-PAGE and probed with anti-acetylated histone antibodies.
Trichostatin A (ab120850)参考文献
This product has been referenced in:
Vigushin DM et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res7:971-6 (2001).
Read more (PubMed: 11309348) »
Suzuki T et al. Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. Int J Cancer88:992-7 (2000).
Read more (PubMed: 11093826) »
Yoshida M et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem265:17174-9 (1990).
Read more (PubMed: 2211619) »