Anti-TRIB3抗体(ab88332)

概述

  • 产品名称Anti-TRIB3抗体
    参阅全部 TRIB3 一抗
  • 描述
    小鼠单克隆抗体to TRIB3
  • 经测试应用适用于: WB, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: PDRATAVATA SRLGPYVLLE PEEGGRAYRA LHCPTGTEYT CKVYPVQEAL AVLEPYARLP PHKHVARPTE VLAGTQLLYA FFTRTHGDMH , corresponding to amino acids 56-145 of Human TRIB3 (AAH27484) with a 26 kDa tag

  • 阳性对照
    • HepG2 cell lysate HeLa cells

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab88332 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa.
ELISA Use at an assay dependent dilution.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
  • 组织特异性Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C20orf97 antibody
    • Neuronal cell death inducible putative kinase antibody
    • Neuronal cell death-inducible putative kinase antibody
    • NIPK antibody
    • p65 interacting inhibitor of NF-kappaB antibody
    • p65-interacting inhibitor of NF-kappa-B antibody
    • SINK antibody
    • SKIP 3 antibody
    • SKIP3 antibody
    • TRB 3 antibody
    • TRB-3 antibody
    • TRB3 antibody
    • TRIB 3 antibody
    • Trib3 antibody
    • TRIB3_HUMAN antibody
    • Tribbles homolog 3 antibody
    • Tribbles pseudokinase 3 antibody
    • Tribbles3 antibody
    see all

Anti-TRIB3 antibody 图像

  • Anti-TRIB3 antibody (ab88332) at 1 µg/ml + Immunogen (recombinant fragment) at 0.2 µg

    Secondary
    Goat anti-mouse IgG at 1/5000 dilution

    Predicted band size : 40 kDa
    Observed band size : 40 kDa
  • Anti-TRIB3 antibody (ab88332) at 1 µg/ml + HepG2 cell lysate at 50 µg

    Secondary
    Goat anti-mouse IgG at 1/5000 dilution

    Predicted band size : 40 kDa
  • Immunofluorescence analysis of TRIB3 in HeLa cells using ab88332 at 10 µg/ml followed by fluorescein conjugated secondary antibody.

Anti-TRIB3 antibody (ab88332)参考文献

ab88332 has not yet been referenced specifically in any publications.

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