Anti-TREM1抗体[6B1] (ab90808)
Key features and details
- Mouse monoclonal [6B1] to TREM1
- Suitable for: WB, Flow Cyt, Functional Studies, IA
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-TREM1抗体[6B1]
参阅全部 TREM1 一抗 -
描述
小鼠单克隆抗体[6B1] to TREM1 -
宿主
Mouse -
特异性
ab90808 recognizes both membrane bound and soluble TREM1. -
经测试应用
适用于: WB, Flow Cyt, Functional Studies, IAmore details -
种属反应性
与反应: Human -
免疫原
Fusion protein Human recombinant TREM1 - IgG1.
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常规说明
ab90808 neutralizes the interaction between TREM1 and its ligand.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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纯化说明
0.2 µm filtered -
Primary antibody说明
ab90808 neutralizes the interaction between TREM1 and its ligand. -
克隆
单克隆 -
克隆编号
6B1 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab90808于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/50.
It is recommended that users test the reagent and determine their own optimal dilutions. |
|
Flow Cyt |
1/50.
It is recommended that users test the reagent and determine their own optimal dilutions. |
|
Functional Studies |
Use at an assay dependent concentration.
|
|
IA |
Use at an assay dependent concentration.
|
说明 |
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WB
1/50. It is recommended that users test the reagent and determine their own optimal dilutions. |
Flow Cyt
1/50. It is recommended that users test the reagent and determine their own optimal dilutions. |
Functional Studies
Use at an assay dependent concentration. |
IA
Use at an assay dependent concentration. |
靶标
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功能
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. -
组织特异性
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. -
序列相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻译后修饰
Glycosylated. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 54210 Human
- Omim: 605085 Human
- SwissProt: Q9NP99 Human
- Unigene: 283022 Human
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别名
- CD354 antibody
- OTTMUSP00000018206 antibody
- TREM 1 antibody
see all
数据表及文件
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Datasheet download
文献 (1)
ab90808 被引用在 1 文献中.
- Campbell GR et al. TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function. mBio 10:N/A (2019). PubMed: 31719184