Anti-Transportin 1抗体(ab67352)

概述

  • 产品名称Anti-Transportin 1抗体
    参阅全部 Transportin 1 一抗
  • 描述
    兔多克隆抗体to Transportin 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Horse, Chicken, Cow, Dog, Human, Xenopus laevis
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 850 to the C-terminus of Human Transportin 1.

    (Peptide available as ab86629.)

  • 阳性对照
    • This antibody gave a positive signal in the following Tissue Lysates: Mouse Liver, Mouse Kidney, Rat Liver, Mouse Pancreas.

性能

应用

Our Abpromise guarantee covers the use of ab67352 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 101 kDa (predicted molecular weight: 101 kDa).

靶标

  • 功能Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
  • 序列相似性Belongs to the importin beta family.
    Contains 8 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Importin 2 antibody
    • Importin beta 2 antibody
    • Importin beta-2 antibody
    • IPO 2 antibody
    • IPO2 antibody
    • Karyopherin (importin) beta 2 antibody
    • Karyopherin beta 2 antibody
    • Karyopherin beta-2 antibody
    • KPN B2 antibody
    • KPNB 2 antibody
    • KPNB2 antibody
    • M9 interacting protein antibody
    • M9 region interacting protein antibody
    • M9 region interaction protein antibody
    • MIP 1 antibody
    • MIP antibody
    • MIP1 antibody
    • OTTHUMP00000126960 antibody
    • OTTHUMP00000222024 antibody
    • OTTHUMP00000226224 antibody
    • TNPO 1 antibody
    • Tnpo1 antibody
    • TNPO1_HUMAN antibody
    • Transportin 1 antibody
    • Transportin antibody
    • Transportin-1 antibody
    • Transportin1 antibody
    • TRN antibody
    see all

Anti-Transportin 1 antibody 图像

  • All lanes : Anti-Transportin 1 antibody (ab67352) at 1 µg/ml

    Lane 1 : Liver (Mouse) Tissue Lysate
    Lane 2 : Kidney (Mouse) Tissue Lysate
    Lane 3 : Liver (Rat) Tissue Lysate
    Lane 4 : Pancreas (Mouse) Tissue Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 101 kDa
    Observed band size : 101 kDa
    Additional bands at : 25 kDa,40 kDa,55 kDa. We are unsure as to the identity of these extra bands.

Anti-Transportin 1 antibody (ab67352)参考文献

ab67352 has not yet been referenced specifically in any publications.

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