Anti-Transglutaminase 5抗体(ab80907)

概述

  • 产品名称Anti-Transglutaminase 5抗体
    参阅全部 Transglutaminase 5 一抗
  • 描述
    兔多克隆抗体to Transglutaminase 5
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide: LGVLKPQHQA SIILETVPFK SGQRQIQANM RSNKFKDIKG YRNVYVDFAL , corresponding to C terminal amino acids 672-721 of Human Transglutaminase 5, (NP_963925).

  • 阳性对照
    • HeLa cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab80907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 37, 42, 80 kDa (predicted molecular weight: 80 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay 1/12500.

靶标

  • 功能Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
  • 组织特异性Expressed in foreskin keratinocytes.
  • 疾病相关Defects in TGM5 are a cause of peeling skin syndrome type A (APSS) [MIM:609796]. A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction.
  • 序列相似性Belongs to the transglutaminase superfamily. Transglutaminase family.
  • 细胞定位Cytoplasm. Associated with intermediate filaments.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Protein glutamine gamma glutamyltransferase 5 antibody
    • Protein-glutamine gamma-glutamyltransferase 5 antibody
    • PSS2 antibody
    • TG(X) antibody
    • TGase 5 antibody
    • TGase X antibody
    • TGase-5 antibody
    • TGase5 antibody
    • TGASEX antibody
    • Tgm5 antibody
    • TGM5_HUMAN antibody
    • TGM6 antibody
    • TGMX antibody
    • TGX antibody
    • Transglutaminase X antibody
    • Transglutaminase-5 antibody
    see all

Anti-Transglutaminase 5 antibody 图像

  • Anti-Transglutaminase 5 antibody (ab80907) at 1 µg/ml + HeLa cell lysate

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 80 kDa
    Observed band size : 80 kDa
    Additional bands at : 37 kDa,42 kDa. We are unsure as to the identity of these extra bands.

Anti-Transglutaminase 5 antibody (ab80907)参考文献

ab80907 has not yet been referenced specifically in any publications.

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