概述

  • 产品名称Anti-TRAF1抗体
    参阅全部 TRAF1 一抗
  • 描述
    山羊多克隆抗体to TRAF1
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide:

    C-KLQSPKHAYVKDD

    , corresponding to C terminal amino acids 392-404 of Human TRAF1

  • 阳性对照
    • U937 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab48002 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1:16,000
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 46 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
    • 序列相似性Contains 1 MATH domain.
    • 结构域The coiled coil domain mediates homo- and hetero-oligomerization.
      The MATH/TRAF domain binds to receptor cytoplasmic domains.
      Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.
    • 翻译后修饰Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
    • Information by UniProt
    • 数据库链接
    • 别名
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      • Tnf receptor associated factor 1 antibody
      • TNF receptor-associated factor 1 antibody
      • TRAF 1 antibody
      • TRAF1 antibody
      • TRAF1_HUMAN antibody
      see all

    Anti-TRAF1 antibody 图像

    Anti-TRAF1 antibody (ab48002)参考文献

    ab48002 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"