概述

  • 产品名称Anti-TPP1抗体
    参阅全部 TPP1 一抗
  • 描述
    山羊多克隆抗体to TPP1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Dog, Chimpanzee, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    C-TPSVIRKRYNLTSQD

    , corresponding to internal sequence amino acids 201-215 of Human TPP1 (NP_000382.3).

  • 阳性对照
    • Human placenta lysate

性能

应用

Our Abpromise guarantee covers the use of ab91512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 61 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
    • 组织特异性Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
    • 疾病相关Defects in TPP1 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2) [MIM:204500]. A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN2 consists of curvilinear profiles.
    • 序列相似性Belongs to the peptidase S53 family.
    • 翻译后修饰Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity.
    • 细胞定位Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cell growth inhibiting gene 1 protein antibody
      • Cell growth-inhibiting gene 1 protein antibody
      • Ceroid lipofuscinosis neuronal 2 antibody
      • Ceroid lipofuscinosis neuronal 2 late infantile (Jansky Bielschowsky disease) antibody
      • Ceroid lipofuscinosis neuronal 2 late infantile antibody
      • CLN 2 antibody
      • CLN2 antibody
      • GIG 1 antibody
      • GIG1 antibody
      • Growth inhibiting protein 1 antibody
      • LPIC antibody
      • Lysosomal pepstatin insensitive protease antibody
      • Lysosomal pepstatin-insensitive protease antibody
      • MGC21297 antibody
      • TPP 1 antibody
      • TPP I antibody
      • TPP-1 antibody
      • TPP-I antibody
      • Tpp1 antibody
      • TPP1_HUMAN antibody
      • TPPI antibody
      • Tripeptidyl aminopeptidase antibody
      • Tripeptidyl peptidase I antibody
      • Tripeptidyl-peptidase 1 antibody
      • Tripeptidyl-peptidase I antibody
      see all

    Anti-TPP1 antibody 图像

    • Anti-TPP1 antibody (ab91512) at 0.3 µg/ml + Human placenta lysate at 35 µg
      Developed using the ECL technique

      Predicted band size : 61 kDa
      Observed band size : 65 kDa (why is the actual band size different from the predicted?)


      Exposure time : 1 hour

    Anti-TPP1 antibody (ab91512)参考文献

    ab91512 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"