Anti-TPOR抗体[EPR4194] (ab109003)

概述

• 产品名称Anti-TPOR抗体[EPR4194]
  参阅全部 TPOR 一抗
• 描述
  兔单克隆抗体[EPR4194] to TPOR
• 经测试应用适用于: WBmore details
• 种属反应性
  与反应: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human TPOR aa 600 to the C-terminus.
  Database link: P40238

• 阳性对照
  • HepG2, A431, and Human marrow lysates.
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated ‘PUR’ on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液pH: 7.20
  Preservative: 0.01% Sodium azide
  Constituents: 40% Glycerol, 0.05% BSA, 59% PBS
• Concentration information loading...
• 纯度Protein A purified
• 克隆单克隆
• 克隆编号EPR4194
• 同种型IgG
• 研究领域
  • Immunology
  • Cell Type Markers
  • CD
  • Platelets

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Thrombocytic Lineage

相关产品

• Positive Controls
  • A431 membrane extract lysate (ab30134)
• Related Products
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)

应用

靶标

• 功能Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
• 组织特异性Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
• 疾病相关Defects in MPL are a cause of congenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]. CAMT is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies.
• 序列相似性Belongs to the type I cytokine receptor family. Type 1 subfamily.
  Contains 2 fibronectin type-III domains.
• 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  The box 1 motif is required for JAK interaction and/or activation.
• 细胞定位Membrane.

• Target information above from: UniProt accession P40238 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 4352 Human
  • Entrez Gene: 17480 Mouse
  • Entrez Gene: 366455 Rat
  • Omim: 159530 Human
  • SwissProt: P40238 Human
  • SwissProt: Q08351 Mouse
  • Unigene: 82906 Human
  • Unigene: 4864 Mouse

  • Unigene: 198731 Rat

  see all
• 别名
  • C MPL antibody
  • CD110 antibody
  • mpl antibody

  • MPLV antibody
  • Myeloproliferative leukemia protein antibody
  • Myeloproliferative leukemia virus oncogene antibody
  • Proto-oncogene c-Mpl antibody
  • THCYT2 antibody
  • Thrombopoietin receptor antibody
  • TPO R antibody
  • TPO-R antibody
  • TPOR antibody
  • TPOR_HUMAN antibody

  see all