概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-DAFEERHKSWGID
    • 氨基酸221 to 233

技术指标

Our Abpromise guarantee covers the use of ab45794 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • HGNC:12014
    • S adenosyl L methionine thiopurine S methyltransferase
    • Thiopurine methyltransferase
    • Thiopurine S methyltransferase
    • Thiopurine S-methyltransferase
    • TPMT
    • TPMT_HUMAN
    see all
  • 功能Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
  • 疾病相关Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency) [MIM:610460]. TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
  • 序列相似性Belongs to the methyltransferase superfamily. TPMT family.
  • 细胞定位Cytoplasm.
  • Information by UniProt

TPMT peptide (221-233) (ab45794)参考文献

ab45794 has not yet been referenced specifically in any publications.

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