Anti-TPH2 (phospho S19)抗体(ab72913)

概述

  • 产品名称Anti-TPH2 (phospho S19)抗体
    参阅全部 TPH2 一抗
  • 描述
    兔多克隆抗体to TPH2 (phospho S19)
  • 特异性ab72913 is specific for TPH2 phosphorylated at Ser19.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Cow, Zebrafish
  • 免疫原

    Synthetic phospho-peptide corresponding to amino acid residues surrounding phospho-Ser19 of rat TPH2.

  • 阳性对照
    • Recombinant TPH2 incubated in the presence of Ca2+/calmodulin dependent kinase II (CaMKII).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
  • 存储溶液Preservative: None
    Constituents: 50% Glycerol, 100µg/ml BSA, 150mM Sodium chloride, 10mM HEPES, pH 7.5
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab72913 is prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab72913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).

靶标

  • 组织特异性Brain specific.
  • 通路Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
  • 疾病相关Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
    Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
  • 序列相似性Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    Contains 1 ACT domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC138871 antibody
    • ADHD7 antibody
    • FLJ37295 antibody
    • MGC138872 antibody
    • Neuronal tryptophan hydroxylase antibody
    • NTPH antibody
    • TPH 2 antibody
    • Tph2 antibody
    • TPH2_HUMAN antibody
    • Tryptophan 5-hydroxylase 2 antibody
    • Tryptophan 5-monooxygenase 2 antibody
    • Tryptophan hydroxylase 2 antibody
    see all

Anti-TPH2 (phospho S19) antibody 图像

  • All lanes : Anti-TPH2 (phospho S19) antibody (ab72913) at 1/1000 dilution

    Lane 1 : recombinant TPH2 (control)
    Lane 2 : recombinant TPH2 incubated in the presence of Ca2+/calmodulin dependent kinase II (CaMKII)


    Predicted band size : 56 kDa
    Observed band size : 56 kDa

Anti-TPH2 (phospho S19) antibody (ab72913)参考文献

ab72913 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab72913.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"