Anti-TPH2 (phospho S19)抗体(ab72913)

概述

  • 产品名称
    Anti-TPH2 (phospho S19)抗体
    参阅全部 TPH2 一抗
  • 描述
    兔多克隆抗体to TPH2 (phospho S19)
  • 特异性
    ab72913 is specific for TPH2 phosphorylated at Ser19.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Cow, Zebrafish
  • 免疫原

    Synthetic phospho-peptide corresponding to amino acid residues surrounding phospho-Ser19 of rat TPH2.

  • 阳性对照
    • Recombinant TPH2 incubated in the presence of Ca2+/calmodulin dependent kinase II (CaMKII).

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
  • 存储溶液
    Preservative: None
    Constituents: 50% Glycerol, 100µg/ml BSA, 150mM Sodium chloride, 10mM HEPES, pH 7.5
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab72913 is prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab72913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).

靶标

  • 组织特异性
    Brain specific.
  • 通路
    Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
  • 疾病相关
    Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
    Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
  • 序列相似性
    Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    Contains 1 ACT domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC138871 antibody
    • ADHD7 antibody
    • FLJ37295 antibody
    • MGC138872 antibody
    • Neuronal tryptophan hydroxylase antibody
    • NTPH antibody
    • TPH 2 antibody
    • Tph2 antibody
    • TPH2_HUMAN antibody
    • Tryptophan 5-hydroxylase 2 antibody
    • Tryptophan 5-monooxygenase 2 antibody
    • Tryptophan hydroxylase 2 antibody
    see all

Anti-TPH2 (phospho S19) antibody 图像

  • All lanes : Anti-TPH2 (phospho S19) antibody (ab72913) at 1/1000 dilution

    Lane 1 : recombinant TPH2 (control)
    Lane 2 : recombinant TPH2 incubated in the presence of Ca2+/calmodulin dependent kinase II (CaMKII)


    Predicted band size : 56 kDa
    Observed band size : 56 kDa

实验方案

Anti-TPH2 (phospho S19) antibody (ab72913)参考文献

ab72913 has not yet been referenced specifically in any publications.

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