概述

  • 产品名称Anti-TORC2抗体
    参阅全部 TORC2 一抗
  • 描述
    兔多克隆抗体to TORC2
  • 特异性These antiboy does not cross react to human lactoferrin, bovine lactoferrin or bovine serum albumin.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to an unique epitope on the Torc2 protein. The peptide was covalently modified post synthetically and covalently coupled to a carrier protein for desired antigenicity before injecting in to rabbits.

性能

应用

Our Abpromise guarantee covers the use of ab88035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/10000.
    WB: 1/500. Detects a band of approximately 85 kDa (predicted molecular weight: 73 kDa). The antibody also labels a 55 kDa protein believed to be a smaller variant of Torc2.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
    • 组织特异性Most abundantly expressed in the thymus. Present in both B and T lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.
    • 序列相似性Belongs to the TORC family.
    • 翻译后修饰Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1. Both insulin and AMPK increase this phosphorylation, of TORC2 while glucagon suppresses it.
    • 细胞定位Cytoplasm. Nucleus. Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CREB regulated transcription coactivator 2 antibody
      • CREB-regulated transcription coactivator 2 antibody
      • CRTC2 antibody
      • CRTC2_HUMAN antibody
      • RP11-422P24.6 antibody
      • TORC-2 antibody
      • torc2 antibody
      • Transducer of CREB protein 2 antibody
      • Transducer of regulated cAMP response element-binding protein antibody
      • Transducer of regulated cAMP response element-binding protein (CREB) 2 antibody
      • Transducer of regulated cAMP response element-binding protein 2 antibody
      • Transducer of regulated CREB protein 2 antibody
      see all

    Anti-TORC2 antibody (ab88035)参考文献

    ab88035 has not yet been referenced specifically in any publications.

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