Topotecan hydrochloride (SK&F 104864) (ab120388)

概述

  • 产品名称Topotecan hydrochloride (SK&F 104864)
  • 描述
    Topoisomerase inhibitor
  • 别名
    • SK&F 104864
  • 生物学描述Topoisomerase I inhibitor. Water-soluble derivative of camptothecin (ab120115). Anticancer agent.
  • 纯度> 98%

性能

  • 化学名称(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride
  • 分子量457.91
  • 化学结构Chemical Structure
  • 分子式C23H23N3O5.HCl
  • CAS编号119413-54-6
  • PubChem识别号60699
  • 存放说明Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in water to 100 mM and in DMSO to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.CN(C)Cc1c2cc3CN4C(=O)C=5COC(=O)[C@](O)(CC)C=5C=C4c3nc2ccc1O
  • 来源

    Synthetic

  • 研究领域

    相关产品

    Topotecan hydrochloride (SK&F 104864) (ab120388)参考文献

    This product has been referenced in:
    • Mathijssen RH  et al. Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan. Curr Cancer Drug Targets 2:103-23 (2002). Read more (PubMed: 12188913) »
    • Tanizawa A  et al. Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 86:836-42 (1994). Read more (PubMed: 8182764) »

    See 0 Publications for this product

    Product Wall

    Thank you for contacting us. The lab has indicated that this compound is not in fact soluble in PBS. We do not have any internal testing on absorabce but some outside info on Topotecan hydrochloride absorabce can be found just doing a google search. Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"