概述

  • 产品名称
  • 描述
    小鼠单克隆抗体to TOP3B
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-863 of Human TOP3B

  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. We would recommend antibody ab183520 as a replacement.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    单克隆
  • 同种型
    IgG2b
  • 轻链类型
    kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab56445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明
    WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Possesses negatively supercoiled DNA relaxing activity.
    • 组织特异性
      Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas.
    • 序列相似性
      Belongs to the prokaryotic type I/III topoisomerase family.
      Contains 1 Toprim domain.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DNA topoisomerase 3 beta 1 antibody
      • DNA topoisomerase 3-beta-1 antibody
      • DNA topoisomerase III beta 1 antibody
      • DNA topoisomerase III beta-1 antibody
      • FLJ39376 antibody
      • TOP 3B antibody
      • TOP3B antibody
      • TOP3B_HUMAN antibody
      • TOP3B1 antibody
      • Topo III beta antibody
      • Topoisomerase (DNA) III beta antibody
      • Topoisomerase DNA III beta antibody
      • Topoisomerase III beta antibody
      see all

    图片



    • Predicted band size : 97 kDa
      TOP3B antibody (ab56445) at 1ug/lane + K-562 cell lysate at 25ug/lane.

    实验方案

    文献

    This product has been referenced in:
    • Yang Y  et al. Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell 53:484-97 (2014). Read more (PubMed: 24507716) »
    • Stoll G  et al. Deletion of TOP3ß, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Nat Neurosci 16:1228-1237 (2013). Read more (PubMed: 23912948) »

    See all 2 Publications for this product

    客户评价及客户问答

    There are currently no Customer reviews or Questions for ab56445.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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