• 产品名称Anti-TNXB抗体
    参阅全部 TNXB 一抗
  • 描述
    小鼠多克隆抗体to TNXB
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Fragment of full length protein (Human) amino acids 1-673.

  • 阳性对照
    • TNXB transfected 293T cell lysate



Our Abpromise guarantee covers the use of ab67586 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: 1/500 - 1/1000. Detects a band of approximately 80 kDa (predicted molecular weight of full length protein: 464 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
    • 组织特异性Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.
    • 疾病相关Tenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
    • 序列相似性Belongs to the tenascin family.
      Contains 19 EGF-like domains.
      Contains 1 fibrinogen C-terminal domain.
      Contains 32 fibronectin type-III domains.
    • 发展阶段Expression levels are lower in adults than in children.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EDS3 antibody
      • Ehlers Danlos like syndrome antibody
      • Growth inhibiting protein 45 antibody
      • Hexabrachion like protein antibody
      • Hexabrachion-like protein antibody
      • HXBL antibody
      • NXB2 antibody
      • Tenascin X precursor antibody
      • Tenascin XB antibody
      • Tenascin XB1 antibody
      • Tenascin XB2 antibody
      • Tenascin-X antibody
      • TENX antibody
      • TENX_HUMAN antibody
      • TN X antibody
      • TN-X antibody
      • TNX antibody
      • TNXB antibody
      • TNXB1 antibody
      • TNXB2 antibody
      • TNXBS antibody
      • VUR8 antibody
      • XB antibody
      • XBS antibody
      see all

    Anti-TNXB antibody 图像

    • All lanes : Anti-TNXB antibody (ab67586) at 1/500 dilution

      Lane 1 : TNXB transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 464 kDa
      Observed band size : 80 kDa (why is the actual band size different from the predicted?)

    Anti-TNXB antibody (ab67586)参考文献

    ab67586 has not yet been referenced specifically in any publications.

    Product Wall

    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Human Tissue sections (tendon)
    Antigen retrieval step None
    Permeabilization No
    Specification tendon
    Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 37°C
    Fixative zinc buffered formalin

    Abcam user community

    Verified customer

    提交于 Nov 03 2015

    Thank you for your reply. I have issued your free of charge replacement with ab24718 on order ***.

    Expiration date: December 6th, 2012

    I am very pleased to hear you would like to accept our offer and test ab8...

    Read More

    Thank you for your reply.

    In order to qualify for the testing discount program, the antibody would need to be purchased for full price. I would be happy to send you this antibody as a free of charge replacement. Alternatively, If you would li...

    Read More

    Thank you for your reply. I am sorry that this antibody is still not working in WB. Yes, we are happy to send you a free of charge replacement antibody. If you have an antibody to TNXB that is working for you, I can send you a replacement with an antib...

    Read More

    Thank you for your reply. I hope that the 4-12% gel will help to visualize the larger molecular weight bands. If not, please let me know and I will be happy to offer you a free of charge replacement with an alternative antibody, or a credit or refund.

    Thank you for your reply. This antibody has not been validated for use on mouse samples. It is possible that it may cross-react, but we do not have any information about how it performs on mouse cells.

    In human samples, we observe an ˜80 kDa ...

    Read More

    Thank you for contacting us. I am sorry that this antibody is not giving any signal in your experiment. I would be happy to help you further if you could please provide some additional information?

    1) What application were you working in (WB,...

    Read More