Anti-TNXB抗体(ab111270)

概述

  • 产品名称
  • 描述
    兔多克隆抗体to TNXB
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    A synthesized peptide derived from an internal region of Human TNXB.

  • 阳性对照
    • Human breast carcinoma tissue.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, PBS, 0.88% Sodium chloride
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab111270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
  • 组织特异性
    Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.
  • 疾病相关
    Tenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性
    Belongs to the tenascin family.
    Contains 19 EGF-like domains.
    Contains 1 fibrinogen C-terminal domain.
    Contains 32 fibronectin type-III domains.
  • 发展阶段
    Expression levels are lower in adults than in children.
  • 细胞定位
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EDS3 antibody
    • Ehlers Danlos like syndrome antibody
    • Growth inhibiting protein 45 antibody
    • Hexabrachion like protein antibody
    • Hexabrachion-like protein antibody
    • HXBL antibody
    • NXB2 antibody
    • Tenascin X precursor antibody
    • Tenascin XB antibody
    • Tenascin XB1 antibody
    • Tenascin XB2 antibody
    • Tenascin-X antibody
    • TENX antibody
    • TENX_HUMAN antibody
    • TN X antibody
    • TN-X antibody
    • TNX antibody
    • TNXB antibody
    • TNXB1 antibody
    • TNXB2 antibody
    • TNXBS antibody
    • VUR8 antibody
    • XB antibody
    • XBS antibody
    see all

图片

  • Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using 1/50 ab111270. The picture on the right is treated with the synthesized peptide

文献

ab111270 has not yet been referenced specifically in any publications.

客户评价及客户问答

Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunohistochemistry free floating
Sample
Mouse Tissue sections (Brain)
Specification
Brain
Username

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提交于 Oct 25 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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