Anti-TNXB抗体(ab111270)

概述

  • 产品名称Anti-TNXB抗体
    参阅全部 TNXB 一抗
  • 描述
    兔多克隆抗体to TNXB
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    A synthesized peptide derived from an internal region of Human TNXB.

  • 阳性对照
    • Human breast carcinoma tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, PBS, 0.88% Sodium chloride
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab111270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
  • 组织特异性Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.
  • 疾病相关Tenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性Belongs to the tenascin family.
    Contains 19 EGF-like domains.
    Contains 1 fibrinogen C-terminal domain.
    Contains 32 fibronectin type-III domains.
  • 发展阶段Expression levels are lower in adults than in children.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EDS3 antibody
    • Ehlers Danlos like syndrome antibody
    • Growth inhibiting protein 45 antibody
    • Hexabrachion like protein antibody
    • Hexabrachion-like protein antibody
    • HXBL antibody
    • NXB2 antibody
    • Tenascin X precursor antibody
    • Tenascin XB antibody
    • Tenascin XB1 antibody
    • Tenascin XB2 antibody
    • Tenascin-X antibody
    • TENX antibody
    • TENX_HUMAN antibody
    • TN X antibody
    • TN-X antibody
    • TNX antibody
    • TNXB antibody
    • TNXB1 antibody
    • TNXB2 antibody
    • TNXBS antibody
    • VUR8 antibody
    • XB antibody
    • XBS antibody
    see all

Anti-TNXB antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using 1/50 ab111270. The picture on the right is treated with the synthesized peptide

Anti-TNXB antibody (ab111270)参考文献

ab111270 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry free floating
Sample Mouse Tissue sections (Brain)
Specification Brain
Username

Abcam user community

Verified customer

提交于 Oct 25 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"