概述

  • 产品名称Anti-TNIK抗体
    参阅全部 TNIK 一抗
  • 描述
    兔多克隆抗体to TNIK
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids of Human TNIK (BAA25477.2).

  • 阳性对照
    • Human Skeletal Muscle tissue.

性能

应用

Our Abpromise guarantee covers the use of ab115619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading.
  • 组织特异性Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CNH domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.
  • 细胞定位Nucleus. Cytoplasm. Recycling endosome. Cytoplasm > cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EC 2.7.11.1 antibody
    • KIAA0551 antibody
    • Tnik antibody
    • TNIK_HUMAN antibody
    • Traf2 and NCK interacting kinase antibody
    • Traf2 and NCK-interacting protein kinase antibody
    see all

Anti-TNIK antibody 图像

  • ab115619, at 5µg/ml, staining TNIK in Formalin-fixed, Paraffin-embedded Human skeletal muscle (myocytes) tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TNIK antibody (ab115619)参考文献

ab115619 has not yet been referenced specifically in any publications.

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