概述

  • 产品名称Anti-TNFRSF1A抗体
    参阅全部 TNFRSF1A 一抗
  • 描述
    兔多克隆抗体to TNFRSF1A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat
  • 免疫原

    Synthetic peptide corresponding to a sequence at the N-terminal of Mouse TNFRSF1A

性能

应用

Our Abpromise guarantee covers the use of ab112535 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa. The detection limit for TNFRSF1A is approximately 2.5ng/lane under non-reducing and reducing conditions.

靶标

  • 功能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
  • 疾病相关Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
  • 序列相似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • 结构域The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
    Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
  • 翻译后修饰The soluble form is produced from the membrane form by proteolytic processing.
  • 细胞定位Cell membrane. Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD120a antibody
    • FPF antibody
    • MGC19588 antibody
    • p55 antibody
    • p55 R antibody
    • P55R antibody
    • p60 antibody
    • TBP 1 antibody
    • TBP1 antibody
    • TBPI antibody
    • TNF R antibody
    • TNF R I antibody
    • TNF R55 antibody
    • TNF-R1 antibody
    • TNF-RI antibody
    • TNFAR antibody
    • TNFR 55 antibody
    • TNFR 60 antibody
    • TNFR antibody
    • TNFR-I antibody
    • TNFR1 antibody
    • TNFR55 antibody
    • TNFR60 antibody
    • TNFRI antibody
    • TNFRSF1A antibody
    • TNR1A_HUMAN antibody
    • Tumor necrosis factor alpha receptor antibody
    • Tumor necrosis factor binding protein 1 antibody
    • Tumor necrosis factor receptor 1 antibody
    • Tumor necrosis factor receptor superfamily member 1A antibody
    • Tumor necrosis factor receptor type 1 antibody
    • Tumor necrosis factor receptor type I antibody
    • Tumor necrosis factor-binding protein 1 antibody
    see all

Anti-TNFRSF1A antibody 图像

  • All lanes : Anti-TNFRSF1A antibody (ab112535)

    Lane 1 : Recombinant Mouse TNFRSF1A protein at 0.01 µg
    Lane 2 : Recombinant Mouse TNFRSF1A protein at 0.005 µg
    Lane 3 : Recombinant Mouse TNFRSF1A protein at 0.0025 µg


    Predicted band size : 50 kDa
  • ab112535 staining TNFRSF1A in Rat intestine by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-TNFRSF1A antibody (ab112535)参考文献

ab112535 has not yet been referenced specifically in any publications.

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