功能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
疾病相关Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
序列相似性Contains 1 death domain. Contains 4 TNFR-Cys repeats.
结构域The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
翻译后修饰The soluble form is produced from the membrane form by proteolytic processing.
Tumor necrosis factor receptor superfamily member 1A antibody
Tumor necrosis factor receptor type 1 antibody
Tumor necrosis factor receptor type I antibody
Tumor necrosis factor-binding protein 1 antibody
Anti-TNFRSF1A antibody 图像
Western blot - Anti-TNFRSF1A antibody (ab107860)
Anti-TNFRSF1A antibody (ab107860) at 1/100 dilution + A549 cell line lysates at 35 µg
Predicted band size : 50 kDa
Anti-TNFRSF1A antibody (ab107860)参考文献
This product has been referenced in:
Al-Zoubi M et al. Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFa completely prevents breast cancer tumor formation in vivo. Cell Cycle12:480-90 (2013).
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