概述

  • 产品名称Anti-TNFAIP1抗体
    参阅全部 TNFAIP1 一抗
  • 描述
    兔多克隆抗体to TNFAIP1
  • 特异性No cross reactivity with other proteins.
  • 经测试应用适用于: ICC, WB, IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to a sequence at the N-terminal of Human TNFAIP1

  • 阳性对照
    • Human rectal cancer tissue; rat brain, heart, lung and thymus tissue lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide, 0.01% Thimerosal (merthiolate)
    Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab86934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use a concentration of 0.25 - 0.5 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
IHC-P Use a concentration of 0.25 - 0.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use a concentration of 0.25 - 0.5 µg/ml.

靶标

  • 功能Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the BACURD family.
    Contains 1 BTB (POZ) domain.
  • 翻译后修饰Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.
  • 细胞定位Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • alpha-induced protein 1 antibody
    • BACD2_HUMAN antibody
    • BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 antibody
    • BTB/POZ domain-containing protein TNFAIP1 antibody
    • endothelial antibody
    • hBACURD2 antibody
    • Protein B12 antibody
    • tnfaip1 antibody
    • Tumor necrosis factor alpha induced protein 1 (endothelial) antibody
    • Tumor necrosis factor alpha induced protein 1 antibody
    • Tumor necrosis factor antibody
    see all

Anti-TNFAIP1 antibody 图像

  • ab86934 at 1µg/ml staining TNFAIP1 in paraffin-embedded human rectal cancer tissue by Immunohistochemistry.
  • All lanes : Anti-TNFAIP1 antibody (ab86934) at 0.5 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat thymus tissue lysate
    Lane 3 : Rat heart tissue lysate
    Lane 4 : Rat lung tissue lysate


    Predicted band size : 36 kDa
    Observed band size : 36 kDa

Anti-TNFAIP1 antibody (ab86934)参考文献

ab86934 has not yet been referenced specifically in any publications.

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