Anti-TNF Receptor II抗体[MR2-1] (Biotin) (ab16920)

概述

  • 产品名称Anti-TNF Receptor II抗体[MR2-1] (Biotin)
    参阅全部 TNF Receptor II 一抗
  • 描述
    小鼠单克隆抗体[MR2-1] to TNF Receptor II (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: WB, IHC-Fr, Flow Cyt, IPmore details
  • 种属反应性
    与反应: Human, Cynomolgus Monkey, Rhesus monkey
  • 免疫原

    Human TNF Receptor II

  • 阳性对照
    • Human lymph node (immunohistochemistry) and PHA activated T cells (flow cytometry).

性能

应用

Our Abpromise guarantee covers the use of ab16920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 55 kDa.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab18434-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.

靶标

  • 功能Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
  • 序列相似性Contains 4 TNFR-Cys repeats.
  • 翻译后修饰Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
    A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD120b antibody
    • p75 antibody
    • p75 TNF receptor antibody
    • p75TNFR antibody
    • p80 TNF alpha receptor antibody
    • p80 TNF-alpha receptor antibody
    • Soluble TNFR1B variant 1 antibody
    • TBP-2 antibody
    • TBPII antibody
    • TNF R II antibody
    • TNF R2 antibody
    • TNF R75 antibody
    • TNF-R2 antibody
    • TNF-RII antibody
    • TNFBR antibody
    • TNFR-II antibody
    • TNFR1B antibody
    • TNFR2 antibody
    • TNFR80 antibody
    • TNFRII antibody
    • Tnfrsf1b antibody
    • TNR1B_HUMAN antibody
    • Tumor necrosis factor beta receptor antibody
    • Tumor necrosis factor receptor 2 antibody
    • Tumor necrosis factor receptor superfamily member 1B antibody
    • Tumor necrosis factor receptor type II antibody
    • Tumor necrosis factor-binding protein 2 antibody
    see all

Anti-TNF Receptor II antibody [MR2-1] (Biotin) (ab16920)参考文献

ab16920 has not yet been referenced specifically in any publications.

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