ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
应用说明Is unsuitable for ICC,IHC-P or IP.
功能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
疾病相关Familial hibernian fever Multiple sclerosis 5
序列相似性Contains 1 death domain. Contains 4 TNFR-Cys repeats.
结构域The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
翻译后修饰The soluble form is produced from the membrane form by proteolytic processing.
细胞定位Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
Tumor necrosis factor receptor superfamily, member 1A antibody
Tumor necrosis factor receptor type 1 antibody
Tumor necrosis factor receptor type I antibody
Tumor necrosis factor-binding protein 1 antibody
Anti-TNF Receptor I antibody [EP1651AY] 图像
Western blot - TNF Receptor I antibody [EP1651AY] (ab68160)
Anti-TNF Receptor I antibody [EP1651AY] (ab68160) at 1/500 dilution + human brain tissue lysate at 10 µg
Secondary HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size : 51 kDa Observed band size : 51 kDa
Anti-TNF Receptor I antibody [EP1651AY] (ab68160)参考文献
This product has been referenced in:
Zhu W et al. Comparison of the properties of human CD146+ and CD146- periodontal ligament cells in response to stimulation with tumour necrosis factor a. Arch Oral Biol58:1791-803 (2013).
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