Anti-TNF Receptor I抗体(ab90463)


  • 产品名称Anti-TNF Receptor I抗体
    参阅全部 TNF Receptor I 一抗
  • 描述
    兔多克隆抗体to TNF Receptor I
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Rat, Sheep, Rabbit, Hamster, Cow, Dog, Human, Pig, Saccharomyces cerevisiae, Xenopus laevis, Drosophila melanogaster, Monkey
  • 免疫原

    Synthetic peptide derived from the sequence of mouse TNF Receptor 1

  • 阳性对照
    • Mouse brain, Rat brain, HeLa (heat shocked) or Jurkat membrane lysate


Our Abpromise guarantee covers the use of ab90463 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IP: Use at a concentration of 12.5 µg/ml.
    WB (ECL): 1/1000. Predicted molecular weight: 51 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
    • 疾病相关Familial hibernian fever
      Multiple sclerosis 5
    • 序列相似性Contains 1 death domain.
      Contains 4 TNFR-Cys repeats.
    • 结构域The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
      Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
    • 翻译后修饰The soluble form is produced from the membrane form by proteolytic processing.
    • 细胞定位Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD120a antibody
      • FPF antibody
      • MGC19588 antibody
      • p55 antibody
      • p55-R antibody
      • p60 antibody
      • TBP1 antibody
      • TBPI antibody
      • TNF R antibody
      • TNF R55 antibody
      • TNF-R1 antibody
      • TNF-RI antibody
      • TNFAR antibody
      • TNFR-I antibody
      • TNFR1 antibody
      • TNFR55 antibody
      • TNFR60 antibody
      • TNFRI antibody
      • TNFRSF1a antibody
      • TNR1A_HUMAN antibody
      • Tumor necrosis factor receptor 1 antibody
      • Tumor necrosis factor receptor superfamily, member 1A antibody
      • Tumor necrosis factor receptor type 1 antibody
      • Tumor necrosis factor receptor type I antibody
      • Tumor necrosis factor-binding protein 1 antibody
      see all

    Anti-TNF Receptor I antibody 图像

    • All lanes : Anti-TNF Receptor I antibody (ab90463) at 1/1000 dilution

      Lane 1 : HeLa (heat shocked) cell extract
      Lane 2 : Jurkat cell extract

      Predicted band size : 51 kDa

    Anti-TNF Receptor I antibody (ab90463)参考文献

    ab90463 has not yet been referenced specifically in any publications.

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