Anti-TNF Receptor I抗体(ab7630)


  • 产品名称Anti-TNF Receptor I抗体
    参阅全部 TNF Receptor I 一抗
  • 描述
    兔多克隆抗体to TNF Receptor I
  • 特异性Does not recognize human sTNFRp75. In ELISA formats and other immunoreactive assays, this antibody will detect the extracellular domain of the TNFRp55 found in human body fluids, particularly in the circulation, urine and supernatants of cells and synovial fluid. This antibody can be used for FACS analysis. Caution should be exhibited as the F(c) domain of the rabbit IgG molecule may interact with cells non-specifically.
  • 经测试应用适用于: Dot blot, ELISA, Flow Cyt, IP, RIA, WBmore details
  • 种属反应性
    与反应: Rabbit
  • 免疫原

    Recombinant fragment corresponding to TNF Receptor I (extracellular).
    Database link: P19438



Our Abpromise guarantee covers the use of ab7630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot
Flow Cyt
  • 应用说明Dot: Use at an assay dependant dilution.
    ELISA: 1/2000 - 1/8000 (against soluble extracellular sTNFRp55 using goat anti-rabbit HRP, ab6721).
    Flow Cyt: Use at an assay dependant dilution.
    IP: 1/400 - 1/800.
    RIA: 1/8000.
    WB: 1/200 - 1/400 using goat anti-rabbit (HRP) ab6721.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
    • 疾病相关Familial hibernian fever
      Multiple sclerosis 5
    • 序列相似性Contains 1 death domain.
      Contains 4 TNFR-Cys repeats.
    • 结构域The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
      Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
    • 翻译后修饰The soluble form is produced from the membrane form by proteolytic processing.
    • 细胞定位Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
    • Information by UniProt
    • 别名
      • CD120a antibody
      • FPF antibody
      • MGC19588 antibody
      • p55 antibody
      • p55-R antibody
      • p60 antibody
      • TBP1 antibody
      • TBPI antibody
      • TNF R antibody
      • TNF R55 antibody
      • TNF-R1 antibody
      • TNF-RI antibody
      • TNFAR antibody
      • TNFR-I antibody
      • TNFR1 antibody
      • TNFR55 antibody
      • TNFR60 antibody
      • TNFRI antibody
      • TNFRSF1a antibody
      • TNR1A_HUMAN antibody
      • Tumor necrosis factor receptor 1 antibody
      • Tumor necrosis factor receptor superfamily, member 1A antibody
      • Tumor necrosis factor receptor type 1 antibody
      • Tumor necrosis factor receptor type I antibody
      • Tumor necrosis factor-binding protein 1 antibody
      see all

    Anti-TNF Receptor I antibody (ab7630)参考文献

    ab7630 has not yet been referenced specifically in any publications.

    Product Wall

    Application Immunoprecipitation
    Sample Human Cell lysate - whole cell (TF-1 cells)
    Total protein in input 30 µg
    Specification TF-1 cells
    Immuno-precipitation step Protein A/G

    Dr. Alison Taylor

    Verified customer

    提交于 Nov 08 2006

    Thank you for your enquiry. We have several antibodies that have been shown to work by immunoprecipitation and western blotting against human receptors 1 and 2. I am assuming that the problem that you are having is due to the fact that you are usin...

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