The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution.
功能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
疾病相关Familial hibernian fever Multiple sclerosis 5
序列相似性Contains 1 death domain. Contains 4 TNFR-Cys repeats.
结构域The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
翻译后修饰The soluble form is produced from the membrane form by proteolytic processing.
细胞定位Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
Tumor necrosis factor receptor superfamily, member 1A antibody
Tumor necrosis factor receptor type 1 antibody
Tumor necrosis factor receptor type I antibody
Tumor necrosis factor-binding protein 1 antibody
Anti-TNF Receptor I antibody [55R-170] (ab106099)参考文献
This product has been referenced in:
Sheehan KC et al. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J Exp Med181:607-17 (1995).
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