Anti-TNF alpha抗体[AS1] (Biotin) (ab16166)


  • 产品名称Anti-TNF alpha抗体[AS1] (Biotin)
    参阅全部 TNF alpha 一抗
  • 描述
    小鼠单克隆抗体[AS1] to TNF alpha (Biotin)
  • 偶联物Biotin
  • 特异性Recognizes human TNF alpha. This antibody also binds baboon TNF alpha. Doesn’t recognize human TNF beta, mouse TNF alpha or a panel of other human cytokines.
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    与反应: Human, Baboon
    不与反应: Mouse
  • 免疫原

    This information is considered to be commercially sensitive.



Our Abpromise guarantee covers the use of ab16166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.

This antibody has been used as a solution phase antibody at 2 µg/ml in a two site ELISA with unconjugated TNF alpha antibody. Typically the ELISA has a working range of 0-10000 pg/ml and a sensitivity of 10 pg/ml with the appropriate standard. Recovery of human TNF alpha in human serum is typically >85% in the ELISA.


  • 功能Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
  • 疾病相关Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
  • 序列相似性Belongs to the tumor necrosis factor family.
  • 翻译后修饰The soluble form derives from the membrane form by proteolytic processing.
    The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
    O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APC1 antibody
    • APC1 protein antibody
    • Cachectin antibody
    • DIF antibody
    • Differentiation inducing factor antibody
    • Macrophage cytotoxic factor antibody
    • Tnf antibody
    • TNF superfamily, member 2 antibody
    • TNF, macrophage derived antibody
    • TNF, monocyte derived antibody
    • TNF-a antibody
    • TNF-alpha antibody
    • TNFA antibody
    • TNFA_HUMAN antibody
    • TNFSF2 antibody
    • Tumor necrosis factor alpha antibody
    • Tumor necrosis factor antibody
    • Tumor necrosis factor ligand superfamily member 2 antibody
    • Tumor Necrosis Factor, Membrane Form antibody
    • Tumor necrosis factor, soluble form antibody
    see all

Anti-TNF alpha antibody [AS1] (Biotin) (ab16166)参考文献

ab16166 has not yet been referenced specifically in any publications.

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