概述

  • 产品名称Anti-TNF alpha抗体
    参阅全部 TNF alpha 一抗
  • 描述
    兔多克隆抗体to TNF alpha
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Sheep, Goat, Horse, Cow, Cat, Dog, Human, Pig, Chimpanzee, Monkey, Baboon, Macaque Monkey, Elk, Bottlenose Dolphin
  • 免疫原

    Recombinant full length protein corresponding to Pig TNF alpha. Recombinant full length mature Pig TNF alpha (154 amino acids) raised in yeast (NP_999187).
    Database link: P23563

  • 阳性对照
    • Recombinant Pig TNF alpha
  • 常规说明Dilute only prior to immediate use.

性能

应用

Our Abpromise guarantee covers the use of ab106606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 16.9 kDa (predicted molecular weight: 25 kDa).
ELISA 1/2000 - 1/2500.

靶标

  • 功能Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
  • 疾病相关Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
  • 序列相似性Belongs to the tumor necrosis factor family.
  • 翻译后修饰The soluble form derives from the membrane form by proteolytic processing.
    The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
    O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APC1 antibody
    • APC1 protein antibody
    • Cachectin antibody
    • DIF antibody
    • Differentiation inducing factor antibody
    • Macrophage cytotoxic factor antibody
    • Tnf antibody
    • TNF superfamily, member 2 antibody
    • TNF, macrophage derived antibody
    • TNF, monocyte derived antibody
    • TNF-a antibody
    • TNF-alpha antibody
    • TNFA antibody
    • TNFA_HUMAN antibody
    • TNFSF2 antibody
    • Tumor necrosis factor alpha antibody
    • Tumor necrosis factor antibody
    • Tumor necrosis factor ligand superfamily member 2 antibody
    • Tumor Necrosis Factor, Membrane Form antibody
    • Tumor necrosis factor, soluble form antibody
    see all

Anti-TNF alpha antibody 图像

  • Anti-TNF alpha antibody (ab106606) at 1 µg/ml + Recombinant Pig TNF alpha

    Secondary
    IRDye800™ Conjugated Goat Anti-Rabbit IgG

    Predicted band size : 25 kDa
    Observed band size : 16.9 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 135 kDa. We are unsure as to the identity of these extra bands.

Anti-TNF alpha antibody (ab106606)参考文献

ab106606 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"