概述

  • 产品名称Anti-TMPRSS3抗体
    参阅全部 TMPRSS3 一抗
  • 描述
    山羊多克隆抗体to TMPRSS3
  • 特异性This antibody is expected to recognise all four reported isoforms.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Orangutan
  • 免疫原

    Synthetic peptide:

    C-EKIVYHSKYKPKR

    , corresponding to internal sequence amino acids 288-300 of Human TMPRSS3.

  • 阳性对照
    • A431 cell lysates

性能

应用

Our Abpromise guarantee covers the use of ab65947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

    Peptide ELISA: antibody detection limit dilution 1:32,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).
    • 组织特异性Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.
    • 疾病相关Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
      Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10) [MIM:605316].
    • 序列相似性Belongs to the peptidase S1 family.
      Contains 1 LDL-receptor class A domain.
      Contains 1 peptidase S1 domain.
      Contains 1 SRCR domain.
    • 翻译后修饰Undergoes autoproteolytic activation.
    • 细胞定位Endoplasmic reticulum membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Deafness autosomal recessive 10 antibody
      • DFNB10 antibody
      • DFNB8 antibody
      • ECHOS1 antibody
      • Gene similar to transmembrane serine protease antibody
      • MGC130589 antibody
      • Serine protease TADG-12 antibody
      • si:dz69g10.3 antibody
      • TADG12 antibody
      • TMPRSS 3 antibody
      • TMPRSS3 antibody
      • TMPS3_HUMAN antibody
      • Transmembrane protease serine 3 antibody
      • Tumor associated differentially expressed gene 12 protein antibody
      • Tumor-associated differentially-expressed gene 12 protein antibody
      • UNQ323/PRO382 antibody
      see all

    Anti-TMPRSS3 antibody 图像

    • Anti-TMPRSS3 antibody (ab65947) at 0.3 µg/ml + A431 cell lysates at 35 µg

      Predicted band size : 49 kDa
      Observed band size : 49 kDa

    Anti-TMPRSS3 antibody (ab65947)参考文献

    ab65947 has not yet been referenced specifically in any publications.

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