Anti-TMPRSS3抗体(ab24158)

概述

  • 产品名称
    Anti-TMPRSS3抗体
    参阅全部 TMPRSS3 一抗
  • 描述
    兔多克隆抗体to TMPRSS3
  • 特异性
    This antibody reacts specifically with human TMPRSS3.
  • 经测试应用
    适用于: WBmore details
  • 免疫原

    A 15 residue synthetic peptide derived from specific domain of human TMPRSS3 protein.

性能

应用

Our Abpromise guarantee covers the use of ab24158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2000. Predicted molecular weight: 49 kDa.

靶标

  • 功能
    Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).
  • 组织特异性
    Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.
  • 疾病相关
    Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10) [MIM:605316].
  • 序列相似性
    Belongs to the peptidase S1 family.
    Contains 1 LDL-receptor class A domain.
    Contains 1 peptidase S1 domain.
    Contains 1 SRCR domain.
  • 翻译后修饰
    Undergoes autoproteolytic activation.
  • 细胞定位
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • 别名
    • Deafness autosomal recessive 10 antibody
    • DFNB10 antibody
    • DFNB8 antibody
    • ECHOS1 antibody
    • Gene similar to transmembrane serine protease antibody
    • MGC130589 antibody
    • Serine protease TADG-12 antibody
    • si:dz69g10.3 antibody
    • TADG12 antibody
    • TMPRSS 3 antibody
    • TMPRSS3 antibody
    • TMPS3_HUMAN antibody
    • Transmembrane protease serine 3 antibody
    • Tumor associated differentially expressed gene 12 protein antibody
    • Tumor-associated differentially-expressed gene 12 protein antibody
    • UNQ323/PRO382 antibody
    see all

图片

  • All lanes : Anti-TMPRSS3 antibody (ab24158)

    Lane 1 : total extract from 293T cells transfected with pHATMPRSS3
    Lane 2 : total extract from 293T cells transfected with pHA (empty vector)

    Lysates/proteins at 40 µg per lane.


    Predicted band size : 49 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)

实验方案

文献

ab24158 has not yet been referenced specifically in any publications.

客户评价及客户问答

Thank you for your patience. I heard back from the lab regarding ab24158:  There is no homology with mouse. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Thank you for your enquiry. This product was raised in rabbit against a mixture of two synthetic peptides : NH2-MGENDPPAVEAPFSFC-COOH (amino acids 1-16 of human TMPRSS3) and NH2-CFLDWIHEQMERDLKT-COOH (amino acids 439-454of human TMPRSS3). As we a...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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