概述

  • 产品名称Anti-TMEM70抗体
    参阅全部 TMEM70 一抗
  • 描述
    兔多克隆抗体to TMEM70
  • 特异性Two isoforms of TMEM70 are known to exist; ab106654 will only recognize Isoform 1. ab106654 is predicted not to cross-react with other TMEM proteins.
  • 经测试应用适用于: IHC-P, ICC/IF, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 14 amino acid synthetic peptide near the center of Human TMEM70 (NP_060336).

  • 阳性对照
    • Human liver tissue lysate; Rat liver tissue

性能

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应用

Our Abpromise guarantee covers the use of ab106654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 5 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 29 kDa.

靶标

  • 功能Involved in biogenesis of mitochondrial ATP synthase.
  • 疾病相关Defects in TMEM70 are a cause of mitochondrial encephalocardiomyopathy neonatal due to ATP synthase deficiency (MT-ATPSD) [MIM:604273]; also known as ATPase deficiency. A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid.
  • 序列相似性Belongs to the TMEM70 family.
  • 细胞定位Mitochondrion inner membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ20533 antibody
    • MC5DN2 antibody
    • OTTHUMP00000226855 antibody
    • OTTHUMP00000226856 antibody
    • TMEM70 antibody
    • TMM70_HUMAN antibody
    • Transmembrane protein 70 antibody
    • Transmembrane protein 70 mitochondrial antibody
    • Transmembrane protein 70, mitochondrial antibody
    see all

Anti-TMEM70 antibody 图像

  • Immunofluorescence of TMEM70 in rat liver tissue with ab106654 at 20 ug/mL.

  • Anti-TMEM70 antibody (ab106654) at 1 µg/ml + Human liver tissue lysate at 15 µg

    Predicted band size : 29 kDa
  • ab106654, at 5 µg/ml, staining TMEM70 in Rat liver tissue by Immunohistochemistry.

Anti-TMEM70 antibody (ab106654)参考文献

ab106654 has not yet been referenced specifically in any publications.

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