概述

  • 产品名称
  • 描述
    兔多克隆抗体to TMEM43
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 194-223 of Human TMEM43 (NP_077310.1).

  • 阳性对照
    • MDA-MB231 cell line lysate.

性能

应用

Our Abpromise guarantee covers the use of ab113116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 45 kDa.

靶标

  • 功能
    May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane.
  • 组织特异性
    Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis.
  • 疾病相关
    Defects in TMEM43 are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5) [MIM:604400]; also known as arrhythmogenic right ventricular cardiomyopathy (ARVC5). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • 序列相似性
    Belongs to the TMEM43 family.
  • 细胞定位
    Endoplasmic reticulum. Nucleus inner membrane. Retained in the inner nuclear membrane through interaction with EMD and A-and B-lamins. The N- and C-termini are orientated towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARVC5 antibody
    • ARVD5 antibody
    • EDMD7 antibody
    • LUMA antibody
    • Protein LUMA antibody
    • Tmem43 antibody
    • TMM43_HUMAN antibody
    • Transmembrane protein 43 antibody
    see all

图片

  • Anti-TMEM43 antibody (ab113116) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

    Predicted band size : 45 kDa

实验方案

文献

This product has been referenced in:

See 1 Publication for this product

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Please note you do not need the above code to place the initial order for ab113116. You only need it to redeem your free primary antibody after you have submitted your Abreview relating your experience testing ab113116 with mouse samples.
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