概述

  • 产品名称Anti-TMEM127抗体
    参阅全部 TMEM127 一抗
  • 描述
    兔多克隆抗体to TMEM127
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide derived from within residues:

    LSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQ

    , corresponding to amino acids 107-156 of Human TMEM127

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab80846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.
  • 组织特异性Widely expressed.
  • 疾病相关Defects in TMEM127 are a cause of susceptibility to pheochromocytoma (PCC) [MIM:171300]. A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
  • 序列相似性Belongs to the TMEM127 family.
  • 细胞定位Cell membrane. Cytoplasm. Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ20507 antibody
    • FLJ22257 antibody
    • TM127_HUMAN antibody
    • Tmem127 antibody
    • Transmembrane protein 127 antibody
    see all

Anti-TMEM127 antibody 图像

  • Anti-TMEM127 antibody (ab80846) at 1 µg/ml + Transfected 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 26 kDa
    Observed band size : 26 kDa
    Additional bands at : 52 kDa. We are unsure as to the identity of these extra bands.

Anti-TMEM127 antibody (ab80846)参考文献

ab80846 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab80846.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"