概述

  • 产品名称
    Anti-TMEM110抗体
  • 描述
    兔多克隆抗体to TMEM110
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit, Cat
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 1-50 of Human TMEM110 (NP_940965).

  • 阳性对照
    • 721_B cell lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab98190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).
  • 组织特异性
    Widely expressed.
  • 序列相似性
    Belongs to the STIMATE family.
  • 结构域
    The GXXXG motif may mediate oligomerization (PubMed:26322679). The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions (PubMed:26644574).
  • 细胞定位
    Endoplasmic reticulum membrane. Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable).
  • Information by UniProt
  • 数据库链接
  • 别名
    • STIM-activating enhancer encoded by TMEM110 antibody
    • STIMA_HUMAN antibody
    • STIMATE antibody
    • Store-operated calcium entry regulator STIMATE antibody
    • Tmem110 antibody
    • Transmembrane protein 110 antibody
    see all

Anti-TMEM110 antibody 图像

  • Anti-TMEM110 antibody (ab98190) at 1 µg/ml + 721_B cell lysate at 10 µg

    Predicted band size : 33 kDa

实验方案

Anti-TMEM110 antibody (ab98190)参考文献

ab98190 has not yet been referenced specifically in any publications.

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