Anti-TLR9抗体- Aminoterminal end (ab53396)

概述

  • 产品名称Anti-TLR9抗体- Aminoterminal end
    参阅全部 TLR9 一抗
  • 描述
    山羊多克隆抗体to TLR9 - Aminoterminal end
  • 经测试应用适用于: WB, ICC, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Chimpanzee
  • 免疫原

    31 amino acid (aa) synthetic peptide

    SLKYNNLTVVPRNLPSSLEYLLLSYNRIVKL

    corresponding to aa 205-235 of the N-terminal domain of Human TLR9

  • 阳性对照
    • Human spleen; mouse spleen; human tonsil.

性能

应用

Our Abpromise guarantee covers the use of ab53396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 115 kDa.
ICC 1/400.
IHC-P Use at an assay dependent dilution.

靶标

  • 功能Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 组织特异性Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 26 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • 细胞定位Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 289 antibody
    • CD289 antibody
    • TLR 9 antibody
    • TLR9 antibody
    • TLR9_HUMAN antibody
    • Toll like receptor 9 antibody
    • Toll like receptor 9 isoform A precursor antibody
    • Toll like receptor 9 isoform B antibody
    • Toll-like receptor 9 antibody
    see all

Anti-TLR9 antibody - Aminoterminal end 图像

  • IH on paraffin section of human spleen using ab53396 at a concentration of 1/250.
  • IH on paraffin section of human tonsil using ab53396 at a concentration of 1/250.
  • IH on paraffin section of mouse spleen using ab53396 at a concentration of 1/250.

Anti-TLR9 antibody - Aminoterminal end (ab53396)参考文献

This product has been referenced in:
  • Thiyagarajan D  et al. Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e. PLoS One 7:e34080 (2012). IHC-P, IHC-Fr ; Human, Mouse . Read more (PubMed: 22479529) »

See 1 Publication for this product

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