Anti-TLR8抗体[44C143] (ab85859)

概述

  • 产品名称Anti-TLR8抗体[44C143]
    参阅全部 TLR8 一抗
  • 描述
    小鼠单克隆抗体[44C143] to TLR8
  • 经测试应用适用于: WB, IHC-P, Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within amino acids 750-850 of Human TLR8

  • 阳性对照
    • Human brain cortex, Human spleen, 293 transfected with human TLR8, and Ramos cells

性能

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应用

Our Abpromise guarantee covers the use of ab85859 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 120 kDa.
IHC-P Use a concentration of 5 µg/ml.
Flow Cyt Use 0.5µg for 106 cells. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 组织特异性Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 23 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 288 antibody
    • CD288 antibody
    • CD288 antigen antibody
    • MGC119599 antibody
    • MGC119600 antibody
    • TLR 8 antibody
    • Tlr8 antibody
    • TLR8_HUMAN antibody
    • Toll like receptor 8 antibody
    • Toll-like receptor 8 antibody
    see all

Anti-TLR8 antibody [44C143] 图像

  • ab85859 at 5 µg/ml staining TLR8 in formalin fixed and paraffin embedded brain cortex
  • ab85859 at 5 µg/ml staining TLR8 in formalin fixed and paraffin embedded spleen tissue
  • Anti-TLR8 antibody [44C143] (ab85859) at 2 µg/ml + 293 cell lysate transfected with Human TLR8

    Predicted band size : 120 kDa
    Observed band size : 120 kDa
  • ab85859 at 0.5µg in 1x106 Ramos cells
    Shaded histogram represents Ramos cells without antibody; green represents isotype control; purple represents TLR8 antibody.

Anti-TLR8 antibody [44C143] (ab85859)参考文献

ab85859 has not yet been referenced specifically in any publications.

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