概述

  • 产品名称Anti-TLR7抗体
    参阅全部 TLR7 一抗
  • 描述
    小鼠单克隆抗体to TLR7
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: ARWFPKTLPC DVTLDVPKNH VIVDCTDKHL TEIPGGIPTN TTNLTLTINH IPDISPASFH RLDHLVEIDF RCNCVPIPLG SKNNMCIKRL QIKPRSFSGL T, corresponding to amino acids 27-127 of Human TLR7 (NP_057646) with a proprietary tag.

  • 阳性对照
    • Daoy cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 121 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 组织特异性Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 27 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • 细胞定位Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PRO285 antibody
    • TLR 7 antibody
    • Tlr7 antibody
    • TLR7_HUMAN antibody
    • Toll like receptor 7 antibody
    • Toll-like receptor 7 antibody
    • UNQ248 antibody
    see all

Anti-TLR7 antibody 图像

  • Anti-TLR7 antibody (ab89509) at 5 µg/ml + Daoy cell lysate at 50 µg

    Predicted band size : 121 kDa
  • Anti-TLR7 antibody (ab89509) at 5 µg/ml + immunogen (101aa recombinant fragment with a tag of 26kDa) at 0.2 µg

    Predicted band size : 121 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

Anti-TLR7 antibody (ab89509)参考文献

ab89509 has not yet been referenced specifically in any publications.

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