概述

  • 产品名称Anti-TLR7抗体
    参阅全部 TLR7 一抗
  • 描述
    兔多克隆抗体to TLR7
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide (Mouse) corresponding to 14 amino acids near the middle of mouse TLR7.

  • 阳性对照
    • Daudi cell lysates.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab24184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 2 µg/ml.
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 122 kDa.

靶标

  • 功能Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 组织特异性Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 27 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • 细胞定位Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PRO285 antibody
    • TLR 7 antibody
    • Tlr7 antibody
    • TLR7_HUMAN antibody
    • Toll like receptor 7 antibody
    • Toll-like receptor 7 antibody
    • UNQ248 antibody
    see all

Anti-TLR7 antibody 图像

  • Lane 1 : Anti-TLR7 antibody (ab24184) at 0.5 µg/ml
    Lane 2 : Anti-TLR7 antibody (ab24184) at 1 µg/ml
    Lane 3 : Anti-TLR7 antibody (ab24184) at 2 µg/ml

    Lane 1 : Daudi cell lysates.
    Lane 2 : Daudi cell lysates.
    Lane 3 : Daudi cell lysates.


    Predicted band size : 122 kDa
  • ab24184 at 2µg/ml staining of TLR7 in Daudi cells by ICC/IF

Anti-TLR7 antibody (ab24184)参考文献

This product has been referenced in:

See 1 Publication for this product

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