Anti-TLR7抗体(ab113524)
Key features and details
- Rabbit polyclonal to TLR7
- Suitable for: WB, IHC-P
- Reacts with: Human, Chimpanzee, Monkey
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-TLR7抗体
参阅全部 TLR7 一抗 -
描述
兔多克隆抗体to TLR7 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human, Chimpanzee, Monkey
预测可用于: Mouse, Rat, Horse, Cow, Dog -
免疫原
Synthetic peptide corresponding to a region within amino acids 900-950 of Human TLR7, conjugated to KLH.
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阳性对照
- Human lung and placenta tissues; Ramos cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA -
Concentration information loading...
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纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab113524于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 121 kDa.
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IHC-P | (1) |
Use a concentration of 10 µg/ml.
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说明 |
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WB
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 121 kDa. |
IHC-P
Use a concentration of 10 µg/ml. |
靶标
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功能
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. -
组织特异性
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. -
序列相似性
Belongs to the Toll-like receptor family.
Contains 27 LRR (leucine-rich) repeats.
Contains 1 TIR domain. -
细胞定位
Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. - Information by UniProt
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数据库链接
- Entrez Gene: 473521 Chimpanzee
- Entrez Gene: 493686 Cow
- Entrez Gene: 491743 Dog
- Entrez Gene: 791248 Horse
- Entrez Gene: 51284 Human
- Entrez Gene: 574291 Monkey
- Entrez Gene: 170743 Mouse
- Entrez Gene: 317468 Rat
see all -
别名
- PRO285 antibody
- TLR 7 antibody
- Tlr7 antibody
see all
图片
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All lanes : Anti-TLR7 antibody (ab113524) at 1 µg/ml
Lane 1 : Ramos cell lysate
Lane 2 : Ramos cell lysate with immunizing peptide
Predicted band size: 121 kDa -
ab113524, at 10 µg/ml, staining TLR7 in formalin fixed, paraffin embedded Human lung tissue by immunohistochemistry.
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ab113524, at 10 µg/ml, staining TLR7 in formalin fixed, paraffin embedded Human placenta tissue by immunohistochemistry.
数据表及文件
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Datasheet download
文献 (2)
ab113524 被引用在 2 文献中.
- Zhu Y et al. Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis. EMBO Mol Med 14:e14455 (2022). PubMed: 34936223
- Feng Y et al. Role of Toll-like receptors in diabetic renal lesions in a miniature pig model. Sci Adv 1:e1400183 (2015). PubMed: 26601192