概述

  • 产品名称Anti-TLR6抗体
    参阅全部 TLR6 一抗
  • 描述
    兔多克隆抗体to TLR6
  • 特异性ab62569 does not recognize TLR1.
  • 经测试应用适用于: ICC, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A peptide corresponding to 13 amino acids near the centre of human TLR6.

  • 阳性对照
    • Jurkat cell lysate. Jurkat cells.

性能

应用

Our Abpromise guarantee covers the use of ab62569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use a concentration of 2 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 92 kDa).

靶标

  • 功能Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.
  • 组织特异性Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 12 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 细胞定位Cell membrane. Cytoplasmic vesicle > phagosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD286 antibody
    • CD286 antigen antibody
    • TLR 6 antibody
    • Tlr6 antibody
    • TLR6_HUMAN antibody
    • Toll like receptor 6 precursor antibody
    • Toll-like receptor 6 antibody
    see all

Anti-TLR6 antibody 图像

  • Lane 1 : Anti-TLR6 antibody (ab62569) at 0.5 µg/ml
    Lane 2 : Anti-TLR6 antibody (ab62569) at 1 µg/ml
    Lane 3 : Anti-TLR6 antibody (ab62569) at 2 µg/ml

    Lane 1 : Jurkat cell lysate
    Lane 2 : Jurkat cell lysate
    Lane 3 : Jurkat cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 92 kDa
    Observed band size : 100 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 110 kDa. We are unsure as to the identity of these extra bands.
  • ab62569, at 2µg/ml, staining TLR6 in Jurkat cells by immunocytochemistry.

Anti-TLR6 antibody (ab62569)参考文献

ab62569 has not yet been referenced specifically in any publications.

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