概述

  • 产品名称Anti-TLR5抗体
    参阅全部 TLR5 一抗
  • 描述
    小鼠单克隆抗体to TLR5
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Cynomolgus Monkey, Rhesus monkey, Orangutan
  • 免疫原

    Recombinant fragment: LYSSNFYGLP KVAYIDLQKN HIAIIQDQTF KFLEKLQTLD LRDNALTTIH FIPSIPDIFL SGNKLVTLPK INLTANLIHL SENRLENLDI LYFLLRVPHL, corresponding to amino acids 351-450 of Human TLR5 (NP_003259) with a 26 kDa proprieraty tag.

  • 阳性对照
    • FHs 173 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89497 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 97 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 组织特异性Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
  • 疾病相关Systemic lupus erythematosus 1
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 22 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 翻译后修饰Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
    Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ10052 antibody
    • MGC126430 antibody
    • MGC126431 antibody
    • SLEB1 antibody
    • TIL 3 antibody
    • TIL3 antibody
    • TLR 5 antibody
    • Tlr5 antibody
    • TLR5_HUMAN antibody
    • Toll like receptor 5 antibody
    • Toll like receptor 5 precursor antibody
    • Toll-like receptor 5 antibody
    • Toll/interleukin 1 receptor like protein 3 antibody
    • Toll/interleukin-1 receptor-like protein 3 antibody
    see all

Anti-TLR5 antibody 图像

  • Anti-TLR5 antibody (ab89497) at 5 µg/ml + FHs 173 whole cell lysate at 50 µg

    Predicted band size : 97 kDa
    Observed band size : 97 kDa
    Additional bands at : 28 kDa. We are unsure as to the identity of these extra bands.

Anti-TLR5 antibody (ab89497)参考文献

ab89497 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89497.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"