概述

  • 产品名称Anti-TLR5抗体
    参阅全部 TLR5 一抗
  • 描述
    山羊多克隆抗体to TLR5
  • 特异性Peptide sequence is < 50 % identical to other human TLR receptors in this region.
  • 经测试应用适用于: WB, ELISA, ICC, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    DLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQ

    , corresponding to amino acids 151-181 of Human TLR5.

  • 阳性对照
    • Human spleen sections or human peripheral blood.
  • 常规说明


    Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • Primary antibody说明Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab1654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100.
ELISA 1/75000.
ICC 1/500.
IHC-P 1/250.

靶标

  • 功能Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 组织特异性Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
  • 疾病相关Systemic lupus erythematosus 1
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 22 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 翻译后修饰Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
    Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ10052 antibody
    • MGC126430 antibody
    • MGC126431 antibody
    • SLEB1 antibody
    • TIL 3 antibody
    • TIL3 antibody
    • TLR 5 antibody
    • Tlr5 antibody
    • TLR5_HUMAN antibody
    • Toll like receptor 5 antibody
    • Toll like receptor 5 precursor antibody
    • Toll-like receptor 5 antibody
    • Toll/interleukin 1 receptor like protein 3 antibody
    • Toll/interleukin-1 receptor-like protein 3 antibody
    see all

Anti-TLR5 antibody 图像

  • Immunohistochemistry with ab1654 on paraffin section of human spleen

Anti-TLR5 antibody (ab1654)参考文献

This product has been referenced in:
  • Kim WY  et al. Increased expression of Toll-like receptor 5 during progression of cervical neoplasia. Int J Gynecol Cancer 18:300-5 (2008). Read more (PubMed: 17587322) »
  • Maaser C  et al. Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin. J Immunol 172:5056-62 (2004). Read more (PubMed: 15067088) »

See all 2 Publications for this product

Product Wall

Thank you for your email. Ab1654 is only available in the form indicated on the online datasheet - PBS, 1mg/ml BSA, 0.1% sodium azide, pH 7.2 - and we can't provide it sodium azide free. If you have any additional questions please contact us again.

We do not have any information about the suitability of this antibody for use in blocking studies.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"