Anti-TLR3抗体[TLR3.7] (Biotin) (ab17264)

概述

• 产品名称Anti-TLR3抗体[TLR3.7] (Biotin)
  参阅全部 TLR3 一抗
• 描述
  小鼠单克隆抗体[TLR3.7] to TLR3 (Biotin)
• 偶联物Biotin
• 经测试应用适用于: Flow Cyt, WB, IHC-Fr, Functional Studies, ICC/IF, IP, IHC-Pmore details
• 种属反应性
  与反应: Mouse, Dog, Human
  
• 免疫原

  Human Flag-tagged TLR3 stably expressed by Ba/F3 cells.

• 阳性对照
  • Monocytes, granulocytes, lymphocytes, human fibroblast, MRC-5 & FS-4 cells.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液Preservative: 0.02% Sodium Azide
  Constituents: 0.1% BSA, PBS
• Concentration information loading...
• 纯度Protein G purified
• 纯化说明0.2 µm filtered
• 克隆单克隆
• 克隆编号TLR3.7
• 同种型IgG1
• 研究领域
  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

  • Immunology
  • Immunoglobulins
  • Receptors

  • Immunology
  • Innate Immunity
  • Chemokines
  • Beta Chemokines (CC)

  • Microbiology
  • Interspecies Interaction
  • Host Virus Interaction

  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • NFkB Pathway

  • Immunology
  • Immune System Diseases
  • Antiviral Signaling

  • Immunology
  • Innate Immunity
  • TLR Signaling

相关产品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

应用

靶标

• 功能Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
• 组织特异性Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
• 疾病相关Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2) [MIM:613002]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.
• 序列相似性Belongs to the Toll-like receptor family.
  Contains 22 LRR (leucine-rich) repeats.
  Contains 1 LRRCT domain.
  Contains 1 LRRNT domain.
  Contains 1 TIR domain.
• 结构域ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.
• 翻译后修饰Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding.
• 细胞定位Endoplasmic reticulum membrane. Endosome membrane.

• Target information above from: UniProt accession O15455 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 7098 Human
  • Entrez Gene: 142980 Mouse
  • Omim: 603029 Human
  • SwissProt: O15455 Human
  • SwissProt: Q99MB1 Mouse
  • Unigene: 657724 Human
  • Unigene: 33874 Mouse
• 别名
  • CD283 antibody
  • CD283 antigen antibody
  • IIAE2 antibody

  • TLR 3 antibody
  • Tlr3 antibody
  • TLR3_HUMAN antibody
  • Toll Like Receptor 3 antibody
  • Toll-like receptor 3 antibody

  see all