Anti-TLR3抗体- Aminoterminal end (ab59918)


  • 产品名称Anti-TLR3抗体- Aminoterminal end
    参阅全部 TLR3 一抗
  • 描述
    兔多克隆抗体to TLR3 - Aminoterminal end
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    A KLH-conjugated synthetic peptide selected from aa 38~53 of mouse TLR3.

  • 阳性对照
    • hepatocarcinoma tissue.



Our Abpromise guarantee covers the use of ab59918 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.


  • 功能Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 组织特异性Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
  • 疾病相关Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2) [MIM:613002]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 22 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
    Contains 1 TIR domain.
  • 结构域ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.
  • 翻译后修饰Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding.
  • 细胞定位Endoplasmic reticulum membrane. Endosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD283 antibody
    • CD283 antigen antibody
    • IIAE2 antibody
    • TLR 3 antibody
    • Tlr3 antibody
    • TLR3_HUMAN antibody
    • Toll Like Receptor 3 antibody
    • Toll-like receptor 3 antibody
    see all

Anti-TLR3 antibody - Aminoterminal end 图像

  • Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ab59918 at a dilution of 1/50. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

Anti-TLR3 antibody - Aminoterminal end (ab59918)参考文献

This product has been referenced in:
  • Agarwal SK  et al. Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts. Arthritis Res Ther 13:R3 (2011). IHC-P ; Human . Read more (PubMed: 21223583) »

See 1 Publication for this product

Product Wall

Thank you for contacting us. Your credit note ID is xxxxx. I am sorry that this antibody did not perform as stated on the datasheet. I have asked our accounting department to issue a credit note for you, which can be redeemed against the invoice ...

Read More