Anti-TLR2抗体[TL2.1] (Biotin) (ab9101)


  • 产品名称
    Anti-TLR2抗体[TL2.1] (Biotin)
    参阅全部 TLR2 一抗
  • 描述
    小鼠单克隆抗体[TL2.1] to TLR2 (Biotin)
  • 偶联物
  • 经测试应用
    适用于: IHC-Fr, Flow Cyt, Functional Studies, IHC-Pmore details
  • 种属反应性
    与反应: Dog, Human, Cynomolgus monkey, Rhesus monkey, Common marmoset
  • 免疫原

    Recombinant human TLR2 produced by the CHO/CD14 reporter cell line.

  • 常规说明

    Ab9101 is a TLR2 function blocking antibody that is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human pheriperal blood mononuclear cells.



Our Abpromise guarantee covers the use of ab9101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab97679-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
Functional Studies Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.


  • 功能
    Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
  • 组织特异性
    Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  • 序列相似性
    Belongs to the Toll-like receptor family.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • 翻译后修饰
    Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • 细胞定位
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD282 antibody
    • CD282 antigen antibody
    • TIL 4 antibody
    • TIL4 antibody
    • TLR 2 antibody
    • TLR2 antibody
    • TLR2_HUMAN antibody
    • Toll like receptor 2 antibody
    • Toll like receptor 2 precursor antibody
    • Toll-like receptor 2 antibody
    • Toll/interleukin 1 receptor like 4 antibody
    • Toll/interleukin 1 receptor like protein 4 antibody
    • Toll/interleukin receptor like protein 4 antibody
    • Toll/interleukin-1 receptor-like protein 4 antibody
    see all

Anti-TLR2 antibody [TL2.1] (Biotin) 图像

  • Immunohistochemical analysis of human TLR2 in paraffin-embedded human spleen tissue.

  • TLR2 staining on human peripheral blood mononuclear cells by using ab9101. Green: CD3+-cells; Red: CD14+ cells.

Anti-TLR2 antibody [TL2.1] (Biotin) (ab9101)参考文献

This product has been referenced in:
  • Flo TH  et al. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 69:474-81 (2001). Read more (PubMed: 11261796) »
  • Wang JE  et al. Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect Immun 69:2402-6 (2001). Read more (PubMed: 11254600) »

See all 3 Publications for this product

Product Wall

The following article describes the use of HM2064 (monoclonal antibody against human TLR-2, clone TL2.1): Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NK...

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