Anti-TLR2抗体[IMG11G5] (ab109810)

概述

  • 产品名称Anti-TLR2抗体[IMG11G5]
    参阅全部 TLR2 一抗
  • 描述
    大鼠单克隆抗体[IMG11G5] to TLR2
  • 经测试应用适用于: WB, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Synthetic peptide against a portion between amino acids 400-450 of Mouse TLR2 (UniProt ID: Q9QUN7).

  • 阳性对照
    • Mouse RAW cell lysate; Thyoglycollate-elicited peritoneal macrophages from C57BL/6 mice

性能

应用

Our Abpromise guarantee covers the use of ab109810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 4 - 6 µg/ml. Predicted molecular weight: 90 kDa.
Flow Cyt Use 2.5µg for 106 cells. ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
  • 组织特异性Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • 翻译后修饰Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD282 antibody
    • CD282 antigen antibody
    • TIL 4 antibody
    • TIL4 antibody
    • TLR 2 antibody
    • TLR2 antibody
    • TLR2_HUMAN antibody
    • Toll like receptor 2 antibody
    • Toll like receptor 2 precursor antibody
    • Toll-like receptor 2 antibody
    • Toll/interleukin 1 receptor like 4 antibody
    • Toll/interleukin 1 receptor like protein 4 antibody
    • Toll/interleukin receptor like protein 4 antibody
    • Toll/interleukin-1 receptor-like protein 4 antibody
    see all

Anti-TLR2 antibody [IMG11G5] 图像

  • Anti-TLR2 antibody [IMG11G5] (ab109810) at 5 µg/ml + Mouse RAW cell lysate at 40 µg

    Secondary
    Goat anti-rat Ig HRP

    Predicted band size : 90 kDa
  • Cell surface flow cytometric analysis of TLR2, using ab109810.
    Thyoglycollate-elicited peritoneal macrophages from C57BL/6 mice were tested with 2.5 µg of isotype control antibody (green) and 2.5 µg of TLR2 antibody (red), and APC-conjugated secondary.

Anti-TLR2 antibody [IMG11G5] (ab109810)参考文献

ab109810 has not yet been referenced specifically in any publications.

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