概述

  • 产品名称Anti-TLR2抗体
    参阅全部 TLR2 一抗
  • 描述
    鸡多克隆抗体to TLR2
  • 经测试应用适用于: WB, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Amino acids 215-410 of TLR2.

性能

应用

Our Abpromise guarantee covers the use of ab14275 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000. Predicted molecular weight: 86 kDa.
Neutralising 1/100.

靶标

  • 功能Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
  • 组织特异性Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  • 序列相似性Belongs to the Toll-like receptor family.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • 翻译后修饰Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD282 antibody
    • CD282 antigen antibody
    • TIL 4 antibody
    • TIL4 antibody
    • TLR 2 antibody
    • TLR2 antibody
    • TLR2_HUMAN antibody
    • Toll like receptor 2 antibody
    • Toll like receptor 2 precursor antibody
    • Toll-like receptor 2 antibody
    • Toll/interleukin 1 receptor like 4 antibody
    • Toll/interleukin 1 receptor like protein 4 antibody
    • Toll/interleukin receptor like protein 4 antibody
    • Toll/interleukin-1 receptor-like protein 4 antibody
    see all

Anti-TLR2 antibody 图像

  • Anti-TLR2 antibody (ab14275) at 1/2000 dilution + Fusion protein derived in E.Coli

    Predicted band size : 86 kDa

Anti-TLR2 antibody (ab14275)参考文献

This product has been referenced in:
  • Yuki T  et al. Activation of TLR2 enhances tight junction barrier in epidermal keratinocytes. J Immunol 187:3230-7 (2011). Neutralising ; Human . Read more (PubMed: 21841130) »
  • Loryman C & Mansbridge J Inhibition of keratinocyte migration by lipopolysaccharide. Wound Repair Regen 16:45-51 (2008). Neutralising ; Human . Read more (PubMed: 18211578) »

See all 2 Publications for this product

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