概述

  • 产品名称
  • 描述
    兔多克隆抗体to TLL1
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human TLL1 aa 874-901 (C terminal) conjugated to keyhole limpet haemocyanin.
    Database link: O43897

  • 阳性对照
    • ZR-75-1 cell line lysate, Human prostate carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab107743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 115 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
  • 疾病相关
    Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6) [MIM:613087]. A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.
  • 序列相似性
    Belongs to the peptidase M12A family.
    Contains 5 CUB domains.
    Contains 2 EGF-like domains.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ASD6 antibody
    • TLL antibody
    • TLL1 antibody
    • TLL1_HUMAN antibody
    • Tolloid like 1 antibody
    • Tolloid-like protein 1 antibody
    see all

图片

  • Anti-TLL1 antibody (ab107743) at 1/100 dilution + ZR-75-1 cell line lysate at 35 µg

    Predicted band size : 115 kDa
    Observed band size : 130 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemistry analysis in formalin fixed and paraffin embedded Human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. ab107743 at a dilution of 1/50.

文献

ab107743 has not yet been referenced specifically in any publications.

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