RabMAb

Anti-TLK1抗体[EPR2886] (ab108987)

概述

  • 产品名称Anti-TLK1抗体[EPR2886]
    参阅全部 TLK1 一抗
  • 描述
    兔单克隆抗体[EPR2886] to TLK1
  • 经测试应用适用于: WB, IP, Flow Cytmore details
    不适用于: ICC or IHC-P
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human TLK1 (UniProt Q9UKI8).

  • 阳性对照
    • HeLa and A431 cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab108987 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 86 kDa (predicted molecular weight: 87 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/100 - 1/500. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • 应用说明Is unsuitable for ICC or IHC-P.
  • 靶标

    • 功能Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
    • 组织特异性Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
    • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
      Contains 1 protein kinase domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • PKU beta antibody
      • PKU-beta antibody
      • serine threonine protein kinase antibody
      • Serine/threonine protein kinase tousled like 1 antibody
      • Serine/threonine-protein kinase tousled-like 1 antibody
      • SNARE protein kinase SNAK antibody
      • Tlk1 antibody
      • TLK1_HUMAN antibody
      • Tousled like kinase 1 antibody
      • Tousled-like kinase 1 antibody
      see all

    Anti-TLK1 antibody [EPR2886] 图像

    • All lanes : Anti-TLK1 antibody [EPR2886] (ab108987) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : A431 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size : 87 kDa
      Observed band size : 86 kDa (why is the actual band size different from the predicted?)

    Anti-TLK1 antibody [EPR2886] (ab108987)参考文献

    ab108987 has not yet been referenced specifically in any publications.

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