Anti-TLK1抗体- C-terminal (ab71744)

概述

  • 产品名称Anti-TLK1抗体- C-terminal
    参阅全部 TLK1 一抗
  • 描述
    兔多克隆抗体to TLK1 - C-terminal
  • 经测试应用适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH

  • 阳性对照
    • HL-60 cell lysate and human hepatocarcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab71744 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Detects a band of approximately 87 kDa (predicted molecular weight: 87 kDa).

靶标

  • 功能Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
  • 组织特异性Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
  • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PKU beta antibody
    • PKU-beta antibody
    • serine threonine protein kinase antibody
    • Serine/threonine protein kinase tousled like 1 antibody
    • Serine/threonine-protein kinase tousled-like 1 antibody
    • SNARE protein kinase SNAK antibody
    • Tlk1 antibody
    • TLK1_HUMAN antibody
    • Tousled like kinase 1 antibody
    • Tousled-like kinase 1 antibody
    see all

Anti-TLK1 antibody - C-terminal 图像

  • Anti-TLK1 antibody - C-terminal (ab71744) at 1/100 dilution + HL-60 cell lysate at 12.5 µg

    Predicted band size : 87 kDa
    Observed band size : 87 kDa
  • ab71744 at 1/50 dilution, staining TLK in human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TLK1 antibody - C-terminal (ab71744)参考文献

ab71744 has not yet been referenced specifically in any publications.

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