ab94118 is a 293T cell transfected lysate in which Human TLE2 has been transiently over-expressed using a pCMV-TLE2 plasmid. The lysate is provided in 1X Sample Buffer. Note: For more detailed how the transfected lysate was prepared view preparation notes
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
Tissue specificity: In all tissues examined, mostly in heart, brain, and muscle.
Similarity: Belongs to the WD repeat Groucho/TLE family.
Contains 6 WD repeats.