概述

  • 产品名称Anti-TIS11D抗体
    参阅全部 TIS11D 一抗
  • 描述
    兔多克隆抗体to TIS11D
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (VGTPVAAAPS SGFAPGFLRR HSASNLHALA HPAPSPGSCS PKFPGAANGS) of Human TIS11D (NP_008818)

  • 阳性对照
    • 721_B cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab84592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation.
  • 疾病相关Defects in ZFP36L2 may be a cause of leukemias. Frameshfits mutations disrupting ZFP36L2 have been found in a patient with acute myeloid leukemia (PubMed:21109922).
  • 序列相似性Contains 2 C3H1-type zinc fingers.
  • 细胞定位Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BRF2 antibody
    • Butyrate response factor 2 antibody
    • C3H1 type-like 2 antibody
    • EGF response factor 2 antibody
    • EGF-response factor 2 antibody
    • ERF 2 antibody
    • ERF-2 antibody
    • ERF2 antibody
    • Protein TIS11D antibody
    • RNF162C antibody
    • TIS11D antibody
    • TISD_HUMAN antibody
    • ZFP36 like 2 antibody
    • ZFP36 ring finger protein like 2 antibody
    • ZFP36-like 2 antibody
    • Zfp36l2 antibody
    • Zinc finger protein 36 antibody
    • Zinc finger protein 36, C3H type like 1 antibody
    • zinc finger protein 36, C3H type like 2 antibody
    • Zinc finger protein 36, C3H1 type like 2 antibody
    • Zinc finger protein, C3H type, 36 like 2 antibody
    see all

Anti-TIS11D antibody 图像

  • Anti-TIS11D antibody (ab84592) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 51 kDa
    Observed band size : 51 kDa
    Additional bands at : 35 kDa. We are unsure as to the identity of these extra bands.
    Gel concentration 12%
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin, dermal fibroblasts tissue labelling TIS11D with ab84592 at 5µg/ml.

Anti-TIS11D antibody (ab84592)参考文献

ab84592 has not yet been referenced specifically in any publications.

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